Protective Potential of Vinpocetine on Acrylamide Induced Liver Toxicity in Male Albino Rats

Acrylamide is a highly reactive carbonyl compound extensively utilized in industrial applications. It shows a significant association with oxidative stress, neurotoxic, and genotoxic effects. This study sought to assess the protective effects of vinpocetine, a synthetic analog of the natural alkaloid vincamine, which exhibits strong antioxidant and anti-inflammatory properties, against ACR-induced hepatic injury. Experimental animals were categorized into four groups and orally treated as follows: control group, Vinpo. group (5 mg/kg bw), Acrylamide group (38.27 mg/kg bw), and Vinpo. plus acrylamide group. Following the experimental period, biochemical analyses revealed that ACR administration significantly elevated hepatic marker enzymes and lipid profile as well as increased oxidative stress markers such as malondialdehyde (MDA) and tumor necrosis factor (TNF-α) immunoexpression levels, with concomitant reductions in antioxidant defenses (catalase "CAT" and superoxide dismutase "SOD"). Conversely, co-administration of vinpocetine mitigated the ACR-induced alterations and helped in the normalization of biochemical parameters, enhancing antioxidant capacity and attenuation of histopathological damage and apoptotic processes.