Cu(I)-Catalyzed 6- <i>endo</i> - <i>dig</i> Annulation of 2-Bromoaryl Enaminones with Terminal Alkynes: Amine Exchange and Modular Access to Enamine Naphthalenones
annulation of 2-bromoaryl enaminones with terminal alkynes proceeding via Cu(III)-acetylide intermediates affords enamine naphthalenones in up to 94% yield, featuring broad substrate scope and good functional group tolerance. Amine exchange enables the modular incorporation of aniline and diverse secondary amines, significantly expanding molecular diversity.
Authors
- Yongbo Zhou (ORCID: https://orcid.org/0000-0002-3540-8618)
- Lebin Su (ORCID: https://orcid.org/0000-0003-1039-0308)
- X X Li
- Shimin Xie (ORCID: https://orcid.org/0009-0007-3970-7512)
- Bo Li (ORCID: https://orcid.org/0000-0002-5802-7519)
- Ke Wang
Institutions
- Hunan University (CN)
- Hunan Normal University (CN)
- Ministry of Education (SA)
- Catalytic Materials (United States) (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/acs.orglett.6c02636
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Hunan Provincial Science and Technology Department