Pre-transplant molecular international prognostic scoring system score reduction is not associated with improved outcomes in myelodysplastic syndromes
Myelodysplastic syndromes (MDS) are hematopoietic disorders characterized by clonal hematopoiesis, recurrent genetic abnormalities, myelodysplasia, and a risk of progression to acute myeloid leukemia (AML) [ 1 , 2 , 3 ]. Despite the availability of various therapeutic interventions such as chemotherapy and hypomethylating agents (HMAs) to delay disease progression, allogeneic hematopoietic stem cell transplantation (HSCT) remains the only curative therapy [ 1 ].
Authors
- Nobuhiro Kanemura (ORCID: https://orcid.org/0000-0001-8449-9918)
- Mitsumasa Watanabe (ORCID: https://orcid.org/0000-0003-4889-7999)
- Mamiko Sakata‐Yanagimoto (ORCID: https://orcid.org/0000-0001-7310-8045)
- Akifumi Takaori‐Kondo (ORCID: https://orcid.org/0000-0001-7678-4284)
- Nobuhiro Hiramoto (ORCID: https://orcid.org/0000-0002-0472-6680)
- Tadakazu Kondo (ORCID: https://orcid.org/0000-0002-8959-6271)
- Seishi Ogawa (ORCID: https://orcid.org/0000-0002-7778-5374)
- Nobuo Sezaki (ORCID: https://orcid.org/0000-0002-0453-5657)
- Toshiyuki Kitano (ORCID: https://orcid.org/0000-0002-4194-1638)
- Senji Kasahara (ORCID: https://orcid.org/0000-0002-1784-2402)
- Yasuhito Nannya (ORCID: https://orcid.org/0000-0002-6526-0992)
- Masataka Sakashita (ORCID: https://orcid.org/0000-0003-3387-1868)
- Junya Kanda (ORCID: https://orcid.org/0000-0002-6704-3633)
- Keiichiro Hattori (ORCID: https://orcid.org/0000-0002-0810-7887)
- Satoshi Yoshihara (ORCID: https://orcid.org/0000-0002-8537-2422)
- Masaaki Tsuji (ORCID: https://orcid.org/0000-0001-5049-2398)
- Takeshi Maeda (ORCID: https://orcid.org/0009-0009-4059-1777)
- Michiko Ichii
- Yasuko Miyahara
- Ko Sasaki
Institutions
- Osaka University of Economics (JP)
- University of Tsukuba (JP)
- Kyoto University (JP)
- Osaka City University (JP)
- Kurashiki Central Hospital (JP)
- Gifu Municipal Hospital (JP)
- Kanazawa University Hospital (JP)
- Kyoto City Hospital (JP)
- Gifu University Hospital (JP)
- University of Tokyo Hospital (JP)
- University of Tsukuba Hospital (JP)
- Chugoku Central Hospital (JP)
- Otsu Red Cross Hospital (JP)
- Hyogo Prefectural Amagasaki General Medical Center (JP)
- Tsukuba Medical Center Hospital (JP)
- Kitano Hospital (JP)
- Kobe City Medical Center General Hospital (JP)
- The University of Tokyo (JP)
- Dokkyo Medical University (JP)
- Hyogo University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Blood Cancer Journal
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1038/s41408-026-01586-9
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science