A Fundamental Source of Misclassification in Single-Concentration Binding Screens
range, ligand-excess design when feasible, concentration control, end-to-end testing of readout additivity and monotonicity, and pilot- or simulation-based assessment of hit-misclassification risk.
Authors
- Sergey N. Krylov (ORCID: https://orcid.org/0000-0003-3270-2130)
- Svetlana M. Krylova (ORCID: https://orcid.org/0000-0002-3291-6721)
- Tong Ye Wang (ORCID: https://orcid.org/0000-0001-9462-7194)
- Toby Chan
Institutions
- York University (CA)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/acs.analchem.6c03234
- Primary Topic
- Cardiac pacing and defibrillation studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- York University