Targeted Affinity Screening Approach for Bioactive Compounds in <i>Curcuma longa</i> Utilizing a Cell-Functionalized Hydrogel
AR-binding candidates. Subsequent bioassays demonstrated their prostate relaxation and antiproliferative activities. This work establishes a biomimetic strategy for receptor-guided ligand screening from complex natural products and expands the toolbox of cell-based bioanalytical platforms for ligand discovery.
Authors
- Sicen Wang (ORCID: https://orcid.org/0000-0002-2757-3277)
- Xiaxi Zhang
- Yinxuan Song
- Fen Wei (ORCID: https://orcid.org/0000-0002-3289-4868)
- Yuxuan Chen (ORCID: https://orcid.org/0000-0003-2327-2511)
- Xinyue Yang (ORCID: https://orcid.org/0009-0002-1968-2091)
- Meihui Zhang
- Luna Zhang
- Yunli Li
- Keyi Lu
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.analchem.6c03264
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00