Dual-Mechanism Antimicrobial Peptides from a Nature-Inspired Scaffold
isolates revealed species-specific susceptibility patterns. Mechanistic investigations demonstrated minimal membrane-lytic activity at concentrations exceeding their MICs, indicating that membrane disruption is not their primary mode of action. In contrast, in vitro transcription/translation assays demonstrated potent inhibition of protein expression. These results demonstrate how targeted sequence refinement can substantially enhance antimicrobial potency while modulating interactions with bacterial membranes and the transcription/translation machinery.
Authors
- Alexandra Stubelius (ORCID: https://orcid.org/0000-0003-4170-8892)
- Johannes Thoma (ORCID: https://orcid.org/0000-0003-3584-8274)
- Alesia A. Tietze (ORCID: https://orcid.org/0000-0002-9281-548X)
- Luisa I. Beyer
- Annie Justh de Neczpal
- Hanna Mårtensson (ORCID: https://orcid.org/0000-0002-6056-1032)
- Åsa Sjöling (ORCID: https://orcid.org/0000-0003-1529-1720)
- Julia Leandersson
- Anne Farewell
- Silvana Lord Smits
- Maya Tabbaa
Institutions
- CNR de la Résistance aux Antibiotiques (FR)
- Center for Translational Molecular Medicine (NL)
- Chalmers University of Technology (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00952
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00