Photoredox-Catalyzed Divergent Functionalizations of α-Trifluoromethyl Alkenes with Alcohols via Single-Electron Oxidation
-retentive anti-Markovnikov hydroalkoxylation. Switching the reaction atmosphere, photocatalyst, and solvent further diverts the same starting materials to defluorinative esterification and aerobic hydroxylative alkoxylation, providing a divergent synthesis of fluorinated and ester-functionalized structures.
Authors
- Lü Yc
- X J Li
- Xin-Yi Hong
- J Liu
- Xiaolin Chen (ORCID: https://orcid.org/0000-0002-5492-516X)
- Ke-Jia Xu
- Lei Fu (ORCID: https://orcid.org/0009-0006-5875-179X)
- Yi-Jing Huang
Institutions
- Fujian Normal University (CN)
- Ministry of Education Science and Technology (MW)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/acs.orglett.6c02645
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province