Spontaneous Intracellular Formation of Covalent Organic Frameworks via Enzyme-Initiated Cascade Reactions to Boost Cancer Radiotherapy
suppresses tumor growth by triggering both ferroptosis and mitotic catastrophe. This strategy bypasses the complex synthesis and purification steps required for conventional nanomedicine. Thus, in situ COF construction is a promising strategy for enhancing cancer radiotherapy, offering a modular platform for the intracellular synthesis of functional bionanomaterials.
Authors
- Bichun Chen
- Qun Guan (ORCID: https://orcid.org/0000-0002-5522-5106)
- Ruibing Wang (ORCID: https://orcid.org/0000-0001-9489-4241)
- Zhiqing Yang (ORCID: https://orcid.org/0000-0003-2017-6583)
- Yanan Li (ORCID: https://orcid.org/0000-0002-7083-4022)
- Le‐Le Zhou
- Wei Zhou
Institutions
- Academy of Medical Sciences (GB)
- University of Macau (MO)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Shandong Normal University (CN)
- Ministry of Education (ME)
- National Center for Tumor Diseases (DE)
- Precision for Medicine (United States) (US)
- Shandong Provincial Hospital (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/jacs.6c07767
- Primary Topic
- Covalent Organic Framework Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00