Discovery of 1 <i>H</i> -Indole-3-Propionamide Derivatives as Potent, Selective and Orally Available Na <sub>V</sub> 1.7 Inhibitors for Pain Treatment
displayed robust analgesic efficacy across various murine models of acute, chronic inflammatory, and neuropathic pain. The findings of the study highlight a highly promising, orally available lead compound for pain treatment.
Authors
- Tingjun Hou (ORCID: https://orcid.org/0000-0001-7227-2580)
- Gaoang Wang (ORCID: https://orcid.org/0000-0002-9831-2090)
- Baolian WANG
- Wu Hh
- Xiangying Liu
- Xi Zhou (ORCID: https://orcid.org/0000-0002-3846-5079)
- Xiaojian Wang (ORCID: https://orcid.org/0000-0002-1856-8820)
- Yizhi Wu (ORCID: https://orcid.org/0000-0001-5704-2111)
- Li‐Ping Bai (ORCID: https://orcid.org/0000-0002-2806-6883)
- Longying Shen
- Xiandao Pan
- Xue Liu
- Lin Wang
- Xi He
- Kai Chen
- Yaling Gong
Institutions
- Shenyang Pharmaceutical University (CN)
- Macau University of Science and Technology (MO)
- Hunan Normal University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- University of Macau (MO)
- Peking Union Medical College Hospital (CN)
- Shanghai Institute of Materia Medica (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00882
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00