Screening and Synergistic Effects of Phenoloxidase Inhibitors in <i>Spodoptera litura</i>
. Bioassays showed that 18 candidate compounds enhanced λ-cyhalothrin toxicity to varying degrees. AG690 (PubChem CID: 3119969) showed the strongest synergistic effect, with synergistic ratios of 1.73, 1.82, and 1.64 at 24, 48, and 72 h, respectively. AG690 reduced PO expression and PO enzymatic activity by 65.79% and 52.41%, respectively, and suppressed cellular immune responses as well as SOD, POD, and lysozyme activities. These findings support PO-targeted immune suppression as a strategy for developing insecticide synergists.
Authors
- Chunping Yang (ORCID: https://orcid.org/0000-0001-5977-6864)
- M H Li
- Huabao Chen (ORCID: https://orcid.org/0000-0003-4792-852X)
- X L Li
- N. Liu
- Rou Ma
- Xiaoyan Qiu
- Jiayun Hu
- Yuan Lu
- Xiaoli Chang
Institutions
- China Tobacco (CN)
- Sichuan Agricultural University (CN)
- People’s Hospital of Wenshan Prefecture (CN)
- Shanghai Pesticide Research Institute (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.jafc.5c16014
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00