Asymmetric Total Synthesis of Fleminchalcone C: A Tyrosinase Inhibitor from <i>Flemingia philippinensis</i>
was developed, highlighted by asymmetric epoxidation to establish the key chiral center. This synthetic access enabled definitive assignment of the absolute configuration and revealed a pronounced stereochemical dependence on tyrosinase inhibitory activity.
Authors
- Feng Gao (ORCID: https://orcid.org/0000-0001-9436-681X)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Lian Sun
- Xiaohuan Li (ORCID: https://orcid.org/0000-0002-7035-5961)
- Nanling Liu
- Zhi-Feng Teng
- Fulian Tang
Institutions
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c02907
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00