Potential Genetic Causal Associations of Systemic Lupus Erythematosus with Five Hematologic Disorders in the European-ancestry Population: A Bidirectional Two-sample Mendelian Randomization Study

Observational studies indicate frequent associations between systemic lupus erythematosus (SLE) and various hematologic disorders, yet causal inferences are limited by confounding and reverse causality. We therefore applied a bidirectional Mendelian randomization (MR) design to assess potential genetic causal associations of SLE with specific hematologic conditions.