A Plastivore Gut System Enables In Vivo Biotransformation and Partial Defluorination of Perfluorooctanoic Acid
OH-associated oxidative signals further showed that larvae reprogrammed metabolism and exhibited a dose-dependent restructuring of the gut redox environment. Low-PFOA conditions were associated with a comparatively coordinated energy and redox state, whereas high-PFOA conditions induced broader stress-associated metabolic reprogramming. These findings provide initial evidence for insect-associated PFOA biotransformation and partial defluorination, and identify plastivore gut systems as a promising biohybrid model for investigating the biological degradation of "forever chemicals" under mild conditions.
Authors
- Bo-Yu Peng (ORCID: https://orcid.org/0000-0002-0585-2654)
- Yazhou Xu (ORCID: https://orcid.org/0000-0002-7827-9182)
- Xuefei Zhou (ORCID: https://orcid.org/0000-0001-6521-0592)
- Yalei Zhang (ORCID: https://orcid.org/0000-0002-3254-8965)
- Wei‐Min Wu (ORCID: https://orcid.org/0000-0001-5244-0655)
- Qianfeng Xu
Institutions
- Tongji University (CN)
- State Key Laboratory of Pollution Control and Resource Reuse (CN)
- Fuzhou University (CN)
- Stanford University (US)
Publication Details
- Journal
- Environmental Science & Technology
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/acs.est.6c06637
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission