Deacylative S <sub>N</sub> 2′-Type Alkylation of Monochloro- and <i>gem</i> -Dichlorocyclobutenones Mediated by Pro-aromatic Intermediates
-dichlorocyclobutenones, contrasting β-selective radical addition in Giese-type addition. This base- and oxidant-free method provides efficient access to highly functionalized 4-alkylated α-chlorocyclobutenones. Furthermore, aldehyde-derived pro-aromatic 4-alkyl-1,4-dihydropyrides served as C-radical precursors, enabling the synthesis of 4-alkylated α-chlorocyclobutenones under similar reaction conditions.
Authors
- Basudev Sahoo (ORCID: https://orcid.org/0000-0002-9746-9555)
- Pinku Prasad Mondal (ORCID: https://orcid.org/0000-0003-4956-9495)
- Sourav Das (ORCID: https://orcid.org/0000-0002-6561-0032)
- Keerthana Somaraj
Institutions
- Indian Institute of Science Education and Research Thiruvananthapuram (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c02578
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00