Lexicon on the Pathomechanics of the Native Hip Joint at Risk for Arthritis

BACKGROUND: Degenerative osteoarthritis (OA) of the hip often arises from structural abnormalities that alter load distribution, which leads to progressive chondrolabral damage. Although substantial advances have been made, the existing terminology in the field of hip preservation remains heterogeneous and inconsistently applied, limiting scientific communication and treatment standardization. The aim of this article is to link evidence from existing literature to develop a framework in the form of a structured lexicon, one that defines the morphological features and pathomechanical mechanisms that are relevant to the symptomatic, pre-arthritic hip. METHODS: This descriptive framework was developed through the synthesis of current biomechanical, radiographic, and clinical evidence, combined with expert consensus from an international, multidisciplinary panel. Foundational concepts were derived from basic science research, including tribology, mechanobiology, and contact mechanics, to establish a unified terminology. RESULTS: Three principal wear modes-instability, impingement, and mixed mechanisms-are proposed, corresponding to distinct pathological loading environments. Wear mechanisms include dysplasia with rim overload and stress-related cartilage failure, impingement with cam-induced shear or pincer rim conflict, and secondary inflammatory degeneration. Wear damage is classified by tissue involvement, encompassing labral degeneration, chondrolabral detachment, staged cartilage delamination, and subchondral bone changes (sclerosis, cystic change). By linking lesion topography to underlying mechanics, this framework has diagnostic and therapeutic relevance as well as encompasses radiographic measurements and clinical features of wear that are pertinent to hip instability and femoroacetabular impingement. CONCLUSIONS: This lexicon provides a coherent framework for pre-arthritic hip disease, establishing a shared terminology to guide basic-science research integration and the interpretation of current clinical practice in hip preservation.

Authors

Institutions

Publication Details

Journal
Journal of Bone and Joint Surgery
Published
2026-07-27
DOI
https://doi.org/10.2106/jbjs.26.00112
Primary Topic
Hip disorders and treatments
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Lexicon on the Pathomechanics of the Native Hip Joint at Risk for Arthritis

Klaus A. Siebenrock, Michael Leunig, Andrew E. Anderson, J. D. WITT et al.
Journal of Bone and Joint Surgery
Hip disorders and treatments
article

Lexicon on the Pathomechanics of the Native Hip Joint at Risk for Arthritis

Klaus A. Siebenrock, Michael Leunig, Andrew E. Anderson, J. D. WITT, Paul E. Beaulé, George Grammatopoulos, Ira Zaltz, Christopher L. Peters, Pierre Laboudie, Michael B. Millis, Marc R. Safran, Martín Beck, John C. F. Clohisy, Nobuhiko Sugano, H.S. Gill, Moritz Wagner, Stephen J. Ferguson
article en

Abstract

BACKGROUND: Degenerative osteoarthritis (OA) of the hip often arises from structural abnormalities that alter load distribution, which leads to progressive chondrolabral damage. Although substantial advances have been made, the existing terminology in the field of hip preservation remains heterogeneous and inconsistently applied, limiting scientific communication and treatment standardization. The aim of this article is to link evidence from existing literature to develop a framework in the form of a structured lexicon, one that defines the morphological features and pathomechanical mechanisms that are relevant to the symptomatic, pre-arthritic hip. METHODS: This descriptive framework was developed through the synthesis of current biomechanical, radiographic, and clinical evidence, combined with expert consensus from an international, multidisciplinary panel. Foundational concepts were derived from basic science research, including tribology, mechanobiology, and contact mechanics, to establish a unified terminology. RESULTS: Three principal wear modes-instability, impingement, and mixed mechanisms-are proposed, corresponding to distinct pathological loading environments. Wear mechanisms include dysplasia with rim overload and stress-related cartilage failure, impingement with cam-induced shear or pincer rim conflict, and secondary inflammatory degeneration. Wear damage is classified by tissue involvement, encompassing labral degeneration, chondrolabral detachment, staged cartilage delamination, and subchondral bone changes (sclerosis, cystic change). By linking lesion topography to underlying mechanics, this framework has diagnostic and therapeutic relevance as well as encompasses radiographic measurements and clinical features of wear that are pertinent to hip instability and femoroacetabular impingement. CONCLUSIONS: This lexicon provides a coherent framework for pre-arthritic hip disease, establishing a shared terminology to guide basic-science research integration and the interpretation of current clinical practice in hip preservation.

Journal of Bone and Joint Surgery
University of Bern (CH), Boston Children's Hospital (US), Harvard University (US), University of Ottawa (CA), Washington University in St. Louis (US), University of Utah (US), University of Michigan (US), Paracelsus Medical University (AT), University Hospital of Bern (CH), Royal London Hospital (GB), ETH Zurich (CH), Institute for Biomedical Engineering (CH), Clinique du Sport (FR), Schulthess-Klinik (CH), Hirslanden Klinik St. Anna (CH), University College London (GB), University of Bath (GB), Stanford University (US), The University of Osaka (JP)
Openalex Percentile: Top 7%
Hip disorders and treatments
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.