A Structural Approach to Identify Promising Natural Compound-Based Lead Candidates against the FemX protein of the ESKAPE pathogen Staphylococcus aureus
FemX (Lipid II: Glycine glycyltransferase) adds the first glycine that forms the interpeptide chain between two muropeptides. Its inhibition weakens cell wall stability, leading to the formation of nonviable cells. Hence, inhibiting FemX might weaken the resistance mechanism against methicillin for Staphylococcus aureus.
Authors
- Shweta Tiwari
- Amit Kumar Singh (ORCID: https://orcid.org/0000-0001-7130-8174)
- Rashmi Prabha Singh (ORCID: https://orcid.org/0000-0003-4475-3007)
- Aarshu Acharya
- Joyabroto Ghosh
- Anjan Kumar Singh (ORCID: https://orcid.org/0009-0003-5538-5032)
- Ankit Kumar (ORCID: https://orcid.org/0009-0008-2713-1912)
Institutions
- Sharda University (IN)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2026-07-27
- DOI
- https://doi.org/10.5281/zenodo.21626176
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00