Asymmetric Fluorocyclization of Enamides Bearing an Alcohol Unit for the Synthesis of Fluorinated Cyclic Ether N,O-Acetals
Chiral 3-fluorinated cyclic ether N,O-acetals were synthesized by the asymmetric fluorocyclization of alcohol-tethered enamides under phase-transfer catalysis. Five-, six-, and seven-membered ring products were obtained from the corresponding cis-enamides enantioselectively in moderate to good yields.
Authors
- Hiromichi Egami (ORCID: https://orcid.org/0000-0002-7784-4987)
- Yoshitaka Hamashima (ORCID: https://orcid.org/0000-0002-6509-8956)
- Mitsuru Kondo (ORCID: https://orcid.org/0000-0002-3946-6882)
- Lio Kurihara
- Chihiro Kanefusa
Institutions
- Shizuoka University (JP)
- University of Shizuoka (JP)
Publication Details
- Journal
- Synlett
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1055/a-2921-9111
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Takeda Science Foundation
- Uehara Memorial Foundation
- Japan Society for the Promotion of Science