Trisulfur Radical Anion (S <sub>3</sub> <sup>•–</sup> )-Promoted Defluorotrisulfuration–Cyclization of Allylic <i>gem</i> -Difluoromethylenes with Elemental Sulfur through C–F and C–H Bond Functionalization
generation of a reactive trisulfur radical anion. Moreover, the distinct reactivity profiles of a series of allylic haloalkyl alkenes are first demonstrated. The one-pot synthesis of the anethole dithiolethione drug is achieved, and the resulting product can be transformed into high-value heterocycles.
Authors
- Xue‐Qiang Chu (ORCID: https://orcid.org/0000-0002-9173-1508)
- Zhi‐Liang Shen (ORCID: https://orcid.org/0000-0002-3365-9288)
- Danhua Ge (ORCID: https://orcid.org/0000-0002-0555-4307)
- Hao Zhu (ORCID: https://orcid.org/0000-0003-4411-0933)
- Mengtao Ma (ORCID: https://orcid.org/0000-0001-9629-6464)
- Ma Qin (ORCID: https://orcid.org/0000-0002-5945-5793)
- Xiao Wang (ORCID: https://orcid.org/0000-0002-4251-9412)
- Li‐Dan Zhang
- Hao Xu
Institutions
- Nanjing Tech University (CN)
- Nanjing Forestry University (CN)
- Fluorochem (United States) (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.orglett.6c02900
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00