Identification and Characterization of Two Multimycotoxin Degrading Enzymes from <i>Klebsiella pneumoniae</i> HNGD-HS06
, ZEN, and AOH by up to 99.16%, 95.12%, and 94.72%, respectively, whereas HSCueO achieved 98.97%, 99.23%, and 99.74% degradation. Product analysis and zebrafish assays suggested that both enzymes transformed these toxins into less toxic products, while molecular docking supported potential enzyme-substrate interactions. Both enzymes retained detoxification activity in contaminated peanut, corn, and wheat flour, expanding enzyme resources for multimycotoxin control in foods.
Authors
- Mule Gk
- Antonio Logrieco (ORCID: https://orcid.org/0000-0002-8606-451X)
- Guanhong Chang
- Yanli Xie (ORCID: https://orcid.org/0000-0002-3895-5959)
- Yuhui Yang (ORCID: https://orcid.org/0000-0002-4949-3745)
- Minjie Hou (ORCID: https://orcid.org/0000-0002-3536-1637)
Institutions
- Turing Institute (GB)
- Center for Food Safety and Applied Nutrition (US)
- Henan University of Technology (CN)
- Shandong Xiehe University (CN)
- Institute of Sciences of Food Production (IT)
- Consorzio Roma Ricerche (IT)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-07-27
- DOI
- https://doi.org/10.1021/acs.jafc.6c07866
- Primary Topic
- Mycotoxins in Agriculture and Food
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China