Cu-Catalyzed Regio- and Diastereoselective Propargylic Substitution of <i>N</i> -Hydroxyphthalimide Esters: Access to Propargyl-Containing <i>N,O</i> -Acetal Derivatives
-acetal products bearing a terminal-alkyne unit in high yields (up to 97%) with excellent diastereoselectivities (up to >19:1 dr) under mild reaction conditions. Moreover, the products serve as versatile intermediates that can be readily transformed into structurally diverse derivatives, offering significant potential for the exploitation of pharmaceutically relevant molecules.
Authors
- X Wang
- Yixuan Cao (ORCID: https://orcid.org/0000-0002-6025-637X)
- Wanqiang Wang (ORCID: https://orcid.org/0000-0002-2483-6887)
- Zhigao Tian
- Wei Wang (ORCID: https://orcid.org/0000-0001-8166-1844)
- Junjie Li (ORCID: https://orcid.org/0000-0002-0868-5636)
- Jie Yang (ORCID: https://orcid.org/0000-0003-4801-7162)
- Peisen Yu
- Yong Zhang
- Yu Zhou
Institutions
- Chinese University of Hong Kong (HK)
- Central China Normal University (CN)
- Institute of Food Science and Technology (CN)
- Hubei University of Arts and Science (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1021/acs.joc.6c00008
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00