Vascular Disease and Diabetes: Prevention, Treatment and Future Regeneration.

Dedicatory to God and human kind magnifica in general (magnifica humanitas). Description / Abstract: A scientific thesis examining the intersection of peripheral artery disease (PAD) and diabetes mellitus as the leading global etiologies of non-traumatic lower-extremity amputations, accounting for over 50% to 80% of lower-limb cases. The work details the six core pathophysiological mechanisms—macrovascular atherosclerosis, microvascular dysfunction, neuropathy, chronic inflammation, immune dysfunction, and fibrosis—driving clinical progression from the at-risk foot to potential amputation.