Connectivity Maintenance Cost: A Thermodynamic Threshold Model for the Failure Sequence of Sustained Biological Networks, with Application to Neurodegeneration

Version 3: adds Section 3 "Mathematical Formulation" and includes the complete mathematical development as Appendix A within the manuscript (closed-form decay dynamics, hub-first ordering under the measurable joint condition α·γ < 1, selective-failure prediction, hysteresis after edge loss). Strengthened literature grounding (Attwell & Laughlin 2001; Harris et al. 2012; Vaishnavi et al. 2010). Abstract, declarations and falsification conditions updated accordingly.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-07-25
DOI
https://doi.org/10.5281/zenodo.21545779
Primary Topic
Gene Regulatory Network Analysis
Type
preprint
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
preprint

Connectivity Maintenance Cost: A Thermodynamic Threshold Model for the Failure Sequence of Sustained Biological Networks, with Application to Neurodegeneration

Sidário Rodrigues Malheiros-junior
Zenodo (CERN European Organization for Nuclear Research)
Gene Regulatory Network Analysis
preprint

Connectivity Maintenance Cost: A Thermodynamic Threshold Model for the Failure Sequence of Sustained Biological Networks, with Application to Neurodegeneration

Sidário Rodrigues Malheiros-junior
preprint en

Abstract

Version 3: adds Section 3 "Mathematical Formulation" and includes the complete mathematical development as Appendix A within the manuscript (closed-form decay dynamics, hub-first ordering under the measurable joint condition α·γ < 1, selective-failure prediction, hysteresis after edge loss). Strengthened literature grounding (Attwell & Laughlin 2001; Harris et al. 2012; Vaishnavi et al. 2010). Abstract, declarations and falsification conditions updated accordingly.

Zenodo (CERN European Organization for Nuclear Research)
Gene Regulatory Network Analysis
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Connectivity Maintenance Cost: A Thermodynamic Threshold Model for the Failure Sequence of Sustained Biological Networks, with Application to Neurodegeneration — Sidário Rodrigues Malheiros-junior · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS