<scp>MEK</scp> Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report
An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.
Authors
- Inbal Hazkani (ORCID: https://orcid.org/0000-0002-8816-7141)
- Rachel D. Yoon (ORCID: https://orcid.org/0009-0009-7065-7909)
- Dana M. Thompson
- Steven Tomasi
- Veronica Drozdowski‐Nuccio
Institutions
- Northwestern University (US)
- Lurie Children's Hospital (US)
Publication Details
- Journal
- The Laryngoscope
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1002/lary.70749
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00