Clozapine for Post-traumatic Stress Disorder: Redefining Treatment Resistance in Soldiers without Psychosis
Post-traumatic stress disorder (PTSD) often follows a chronic trajectory, with many patients failing to respond to first-line psychotherapy and SSRIs/SNRIs. This case series explores clozapine for treatment-resistant PTSD (TR-PTSD) without psychosis. Seven soldiers showed improved function and reduced aggression at doses of 125–300 mg, suggesting that clozapine warrants further investigation.
Authors
- Miyuru Chandradasa (ORCID: https://orcid.org/0000-0002-1873-8228)
- R. M. M. Monaragala (ORCID: https://orcid.org/0009-0006-1506-9088)
- K.A.L.A. Kuruppuarachchi (ORCID: https://orcid.org/0000-0002-8380-2329)
Institutions
- University of Kelaniya (LK)
- General Sir John Kotelawala Defence University (LK)
- United States Army (US)
Publication Details
- Journal
- Indian Journal of Psychological Medicine
- Published
- 2026-07-26
- DOI
- https://doi.org/10.1177/02537176261469995
- Primary Topic
- Posttraumatic Stress Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00