Real‐World Treatment Patterns and Physician Perspectives in Relapsed/Refractory Multiple Myeloma: Results From a Nationwide Italian GIMEMA Survey
Background: The management of relapsed/refractory multiple myeloma (RRMM) remains complex due to early exposure to multiple drug classes since the first treatment line. Aims: To evaluate treatment patterns and identify unmet clinical needs in RRMM across Italian hematology centers. Methods: A national survey was conducted among hematologists experienced in MM care and working in 71 centers, collecting aggregated data on treatment lines, regimens, and clinician perceptions. Results: Upfront daratumumab-based regimens were used most frequently. Lenalidomide and anti-CD38 refractoriness emerged early, limiting options in 2L/3L. Anti-BCMA therapies were broadly endorsed. Conclusions: Despite therapeutic advances for MM, real-world data reveal significant treatment variability and reinforce the need for shared guidelines and innovative therapies. : The authors have confirmed clinical trial registration is not needed for this submission.
Authors
- Paola Fazi (ORCID: https://orcid.org/0000-0002-4211-9240)
- Alfonso Piciocchi (ORCID: https://orcid.org/0000-0001-8648-885X)
- Valeria Sargentini
- Messina Messina
- Paolo de Fabritiis (ORCID: https://orcid.org/0000-0002-1835-0581)
- Sara Bringhen (ORCID: https://orcid.org/0000-0003-4539-6363)
- Francesca Fazio (ORCID: https://orcid.org/0000-0003-4187-8912)
- E Zamagni
- P Musto
- Stefano Soddu (ORCID: https://orcid.org/0000-0002-1942-1230)
- F Di Raimondo
- Massimo Gentile (ORCID: https://orcid.org/0000-0002-5256-0726)
- Michele Cavo
- MariaTeresa Petrucci
- Francesca Patriarca
- Giuseppe Mele
- Maurizio Offidani
Institutions
- Marche Polytechnic University (IT)
- University of Udine (IT)
- Policlinico Umberto I (IT)
- University of Catania (IT)
- Ospedali Riuniti di Ancona (IT)
- Fondazione Gimema Onlus (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Policlinico Universitario di Catania (IT)
- Ospedale Annunziata di Cosenza (IT)
- Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo (IT)
- Gruppo Italiano per il Trapianto di Midollo Osseo (IT)
- University of Calabria (IT)
- University of Bari Aldo Moro (IT)
- University of Bologna (IT)
Publication Details
- Journal
- eJHaem
- Published
- 2026-07-25
- DOI
- https://doi.org/10.1002/jha2.70354
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00