From scope to strategy: Recent advances in Suzuki cross-coupling for efficient total synthesis and molecule editing

The Suzuki-Miyaura cross-coupling reaction has emerged as a cornerstone in the field of organic synthesis, particularly for the formation of carbon–carbon (C–C) bonds critical in the construction of complex natural products and pharmaceuticals. We further analyze over 60 recent case studies (2018-2025) demonstrating the reaction's versatility in both inter- and intramolecular applications across diverse structural frameworks. The reaction's broad substrate scope, functional group tolerance, and adaptability to various solvents and ligands highlight its indispensable role in modern synthetic chemistry.