Photothermal Biomodulated Autologous PRP Combined with Laser and LED Phototherapy for Acne Sequela: A Report of Three Illustrative Cases

Background: Acne vulgaris may lead to persistent sequelae, including post-inflammatory erythema, hyperpigmentation, and atrophic scarring. Multimodal regenerative approaches combining autologous biological therapies with light-based devices are increasingly used in clinical practice, although published clinical evidence remains limited. Case Presentations: We report three female patients with distinct acne-related skin sequelae: (1) post-inflammatory erythema with active inflammatory lesions, (2) post-inflammatory hyperpigmentation with residual acne activity, and (3) atrophic acne scarring. Each patient was treated with a tailored multimodal protocol combining photothermal biomodulated autologous platelet-rich plasma (PRP), laser therapy (non-ablative or ablative erbium-doped yttrium aluminium garnet), and light-emitting diode (LED) phototherapy. Clinical outcomes were retrospectively assessed using serial clinical photographs obtained during routine follow-up. Where image quality allowed, approximate inflammatory lesion counts and semi-quantitative ordinal estimates of erythema, hyperpigmentation, scar visibility, and texture change were added post hoc. Follow-up ranged from 1 month to 12 months. Results: All three patients showed photographic improvement in inflammatory activity, pigmentation, skin texture, and/or scar appearance at available follow-up time points. Treatments were well tolerated, with only transient local reactions such as redness and swelling. Conclusions: These case reports illustrate the feasibility and tolerability of combining photothermal biomodulated autologous PRP with laser and LED therapies for different acne sequelae. Because no validated objective scoring system was applied prospectively, the findings should be interpreted as descriptive and hypothesis-generating. These observations support further controlled studies to evaluate standardized protocols and clinical outcomes.