Rhodium‐Catalyzed Synthesis of Enantioenriched α‐Substituted Primary Amines Through Asymmetric Transfer Hydrogenation
The preparation of a series of enantioenriched α-substituted primary amines using rhodium-catalyzed asymmetric transfer hydrogenation of ortho-hydroxyaryl N─H imines is reported. The reaction proceeds under mild conditions using a low catalyst loading and ammonium formate as the hydrogen source, delivering the reduced compounds in high yields (up to 99%) and enantioselectivities (up to 99% ee).
Authors
- Guillaume Lefèvre (ORCID: https://orcid.org/0000-0001-9409-5861)
- Qin Yin (ORCID: https://orcid.org/0000-0003-3534-3786)
- C. Tony Liu
- Phannarath Phansavath (ORCID: https://orcid.org/0000-0002-7854-170X)
- Virginie Ratovelomanana‐Vidal (ORCID: https://orcid.org/0000-0003-1167-1195)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Shenzhen University (CN)
- Shenzhen Technology University (CN)
- Health & Life (Taiwan) (TW)
Publication Details
- Journal
- Chemistry - A European Journal
- Published
- 2026-07-24
- DOI
- https://doi.org/10.1002/chem.71466
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council