Validity of HINT-8 in evaluating health-related quality of life among cervical cancer patients

Aim: Cervical cancer, caused primarily by human papillomavirus infection, affects patients' health-related quality of life (HRQoL). Despite research on quality of life in cancer patients, studies using the HINT-8 instrument, especially for cervical cancer, are scarce. This study evaluates the validity of HINT-8 in measuring HRQoL among Korean cervical cancer patients by comparing it with EQ-5D-5L. Materials & methods: Demographic and clinical characteristics were analyzed. Mean, median and standard deviations for each domain of both instruments were calculated. Spearman and Pearson correlation coefficients assessed relationships between HINT-8 and EQ-5D-5L indices and domains. Results: Increased problem intensity in HINT-8 domains (e.g., stair climbing, pain and vitality) was correlated with decreased EQ-5D-5L index, indicating a higher response level in HINT-8 aligns with lower EQ-5D-5L scores. Significant variables were consistent across tools, showing no substantial functional difference. A strong correlation between HINT-8 and EQ-5D-5L indices (r = 0.771, p < 0.01) supports HINT-8’s effectiveness in evaluating HRQoL for cervical cancer patients. Conclusion: The HINT-8 demonstrated a strong correlation with the EQ-5D-5L index and a substantially lower ceiling effect, suggesting that it can capture subtle differences in HRQoL among cervical cancer patients. Furthermore, the HINT-8 may provide complementary information beyond the EQ-5D-5L by capturing distinct dimensions such as memory, sleep and happiness, which are not explicitly represented in the EQ-5D-5L descriptive system. These findings support the validity of the HINT-8 as a complementary instrument for assessing HRQoL in Korean cervical cancer patients.

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Publication Details

Journal
Journal of Comparative Effectiveness Research
Published
2026-07-24
DOI
https://doi.org/10.57264/cer-2025-0194
Primary Topic
Cancer survivorship and care
Type
article
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article

Validity of HINT-8 in evaluating health-related quality of life among cervical cancer patients

Soo Hyun Lee, Tae‐Wook Kong, Youn Jin Choi, Byung Su Kwon et al.
Journal of Comparative Effectiveness Research
Cancer survivorship and care
article

Validity of HINT-8 in evaluating health-related quality of life among cervical cancer patients

Soo Hyun Lee, Tae‐Wook Kong, Youn Jin Choi, Byung Su Kwon, Sung Taek Park, Kyung‐Jin Min, Su‐Yeon Yu, Hyunji Lim, Jing An, Min Chul Choi, Jung‐Yun Lee, Kyeong A So, Guibin Hong, Won Moo Lee, Jae Kwan Lee, Tae‐Hwe Heo, Dae Hoon Jeong, Woo-Jeong Sim, Ah-Yeon Lee, Min-Ju Kim
article en

Abstract

Aim: Cervical cancer, caused primarily by human papillomavirus infection, affects patients' health-related quality of life (HRQoL). Despite research on quality of life in cancer patients, studies using the HINT-8 instrument, especially for cervical cancer, are scarce. This study evaluates the validity of HINT-8 in measuring HRQoL among Korean cervical cancer patients by comparing it with EQ-5D-5L. Materials & methods: Demographic and clinical characteristics were analyzed. Mean, median and standard deviations for each domain of both instruments were calculated. Spearman and Pearson correlation coefficients assessed relationships between HINT-8 and EQ-5D-5L indices and domains. Results: Increased problem intensity in HINT-8 domains (e.g., stair climbing, pain and vitality) was correlated with decreased EQ-5D-5L index, indicating a higher response level in HINT-8 aligns with lower EQ-5D-5L scores. Significant variables were consistent across tools, showing no substantial functional difference. A strong correlation between HINT-8 and EQ-5D-5L indices (r = 0.771, p < 0.01) supports HINT-8’s effectiveness in evaluating HRQoL for cervical cancer patients. Conclusion: The HINT-8 demonstrated a strong correlation with the EQ-5D-5L index and a substantially lower ceiling effect, suggesting that it can capture subtle differences in HRQoL among cervical cancer patients. Furthermore, the HINT-8 may provide complementary information beyond the EQ-5D-5L by capturing distinct dimensions such as memory, sleep and happiness, which are not explicitly represented in the EQ-5D-5L descriptive system. These findings support the validity of the HINT-8 as a complementary instrument for assessing HRQoL in Korean cervical cancer patients.

Journal of Comparative Effectiveness Research
Kangwon National University (KR), Yonsei University (KR), Kongju National University (KR), Konkuk University (KR), Korea University Medical Center (KR), Ansan University (KR), Konkuk University Medical Center (KR), St. Mary's Hospital (US), Hallym University Kangnam Sacred Heart Hospital (KR), Inje University Busan Paik Hospital (KR), Kyung Hee University Medical Center (KR), CHA University Bundang Medical Center (KR), CHA University (KR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Korea University (JP), Gongju National University of Education (KR), Hanyang University (KR), Ajou University (KR), Catholic University of Korea (KR)
Openalex Percentile: Top 11%
Cancer survivorship and care
DOIOpen Access PDFOpenAlex
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