Leiomodin2 is a polymerase at the pointed ends of actin filaments
Biophysical and structural studies have found that leiomodin 2, a protein discovered in muscle cells, is the first example of a molecule that promotes the elongation of actin filaments at their slowly growing “pointed ends.” This breakthrough will stimulate work to answer many puzzling questions about the mechanism of this process.
Authors
- Thomas D. Pollard (ORCID: https://orcid.org/0000-0002-1785-2969)
Institutions
- Yale University (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-07-24
- DOI
- https://doi.org/10.1038/s41467-026-75794-z
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00