Leiomodin2 is a polymerase at the pointed ends of actin filaments

Biophysical and structural studies have found that leiomodin 2, a protein discovered in muscle cells, is the first example of a molecule that promotes the elongation of actin filaments at their slowly growing “pointed ends.” This breakthrough will stimulate work to answer many puzzling questions about the mechanism of this process.

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Publication Details

Journal
Nature Communications
Published
2026-07-24
DOI
https://doi.org/10.1038/s41467-026-75794-z
Primary Topic
Cardiomyopathy and Myosin Studies
Type
article
Field-Weighted Citation Impact
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article

Leiomodin2 is a polymerase at the pointed ends of actin filaments

Thomas D. Pollard
Nature Communications
Cardiomyopathy and Myosin Studies
article

Leiomodin2 is a polymerase at the pointed ends of actin filaments

Thomas D. Pollard
article en

Abstract

Biophysical and structural studies have found that leiomodin 2, a protein discovered in muscle cells, is the first example of a molecule that promotes the elongation of actin filaments at their slowly growing “pointed ends.” This breakthrough will stimulate work to answer many puzzling questions about the mechanism of this process.

Nature CommunicationsVol. 17(1)
Yale University (US), University of California, Berkeley (US)
Openalex Percentile: Top 9%
Cardiomyopathy and Myosin Studies
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