Synthesis, molecular docking and biological evaluation of coumarin based isoxazoles and benzoimidazoles

In this paper, we described the synthesis of coumarin moiety based Isoxazoles and Benzoimidazoles. The 4-hydroxy coumarin with POCl 3 were refluxed to get 4-chloro-2H-chromen-2-one which is reacted with 1-(2-mercapto-1H-benzo[d]imidazol-5-yl)ethanone will give compound (2). The cyclization of compounds (3a-e) with hydroxyl amine hydrochloride, resulted in corresponding coumarin isoxazoles (4a-e). The newly synthesized compounds’ structures were determined using elemental analysis, 1 H NMR, 13 C NMR and mass spectrum data. The compounds generated were evaluated for antimicrobial effects. Molecular docking studies were also carried out to know the inhibitory effect of the synthesized compounds.