<scp>ALT</scp> phenotype assessment in <scp>IDH</scp> ‐mutant astrocytoma supports biologic consequence of <scp> <i>ATRX</i> </scp> missense mutations
A meaningful subset of IDH-mutant astrocytoma harbors ATRX missense variants that retain ATRX IHC immunoreactivity yet exhibit functional ALT activation, supporting the biologic relevance of these missense mutations.
Authors
- David Kamson (ORCID: https://orcid.org/0000-0002-0473-658X)
- Calixto‐Hope G. Lucas (ORCID: https://orcid.org/0000-0002-8347-9592)
- Kevin Y. Zhang (ORCID: https://orcid.org/0000-0002-2074-6876)
- A K Meeker
- Solmaz Sahebjam (ORCID: https://orcid.org/0000-0001-9930-9937)
- Karisa C. Schreck (ORCID: https://orcid.org/0000-0001-7181-3269)
- Chetan Bettegowda (ORCID: https://orcid.org/0000-0001-9991-7123)
- Matthias Holdhoff (ORCID: https://orcid.org/0000-0002-3285-3484)
- Charles G. Eberhart
- OO Kizilkaya (ORCID: https://orcid.org/0009-0004-3777-5894)
- Victoria Croog
- Mohamed Sherief
- Jordina Rincon‐Torroella
- Debraj Mukherjee
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Baltimore (US)
Publication Details
- Journal
- Brain Pathology
- Published
- 2026-07-24
- DOI
- https://doi.org/10.1111/bpa.70126
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00