Longitudinal in vivo imaging reveals asynchronous, incomplete Nipah virus clearance with prolonged focal CNS involvement in IFNAR <sup>−/−</sup> mice
mice. Integration with RT-qPCR, histopathology, and in situ hybridization showed persistent viral RNA in discrete brain regions after apparent clinical recovery, indicating anatomically restricted persistence. Together, these findings reveal the spatiotemporal dynamics of incomplete NiV clearance in vivo and provide a framework to study relapsing disease.
Authors
- Jessica R. Spengler (ORCID: https://orcid.org/0000-0002-5383-0513)
- Jana M. Ritter (ORCID: https://orcid.org/0000-0002-4768-162X)
- Stephen R. Welch (ORCID: https://orcid.org/0000-0002-6905-8521)
- César G. Albariño (ORCID: https://orcid.org/0000-0002-8013-1785)
- Shilpi Jain (ORCID: https://orcid.org/0000-0002-5638-0298)
- Katherine Davies (ORCID: https://orcid.org/0000-0002-1643-7093)
- JoAnn D. Coleman-McCray (ORCID: https://orcid.org/0000-0003-0396-2224)
- Christina F. Spiropoulou (ORCID: https://orcid.org/0000-0001-8406-3161)
- Michael K. Lo (ORCID: https://orcid.org/0000-0002-0409-7896)
- Joel M. Montgomery (ORCID: https://orcid.org/0000-0003-0523-4431)
- Teresa E. Sorvillo (ORCID: https://orcid.org/0000-0003-2943-4040)
- G Ficarra (ORCID: https://orcid.org/0000-0002-1210-8516)
- Virginia Aida-Ficken (ORCID: https://orcid.org/0000-0001-9450-0142)
Institutions
- United States Department of Agriculture (US)
Publication Details
- Journal
- Emerging Microbes & Infections
- Published
- 2026-07-24
- DOI
- https://doi.org/10.1080/22221751.2026.2703394
- Primary Topic
- Virology and Viral Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Energy
- Bill and Melinda Gates Foundation
- Oak Ridge Associated Universities
- Oak Ridge Institute for Science and Education
- Agricultural Research Service