Efficiency of nanovaccines compared with antibiotic therapy in the prevention and immunomodulation of listeriosis
Although the main antimicrobial therapy for adult and neonatal listeriosis is ampicillin, prophylactic treatments are currently lacking. We compared the efficiency of nanovaccines with prenatal or postnatal ampicillin treatments in pregnant female mice during the development of neonatal listeriosis. Nanovaccines prepared with gold nanoparticles and listeriolysin O (LLO) or glyceraldehyde-3-phosphate dehydrogenase (GAPDH) peptides and inoculated into pregnant females, prevented neonatal listeriosis and the appearance of comorbidities, better than pre or postnatal ampicillin treatment. Evaluation of the ability of nanovaccines as immunomodulators of blood cells in patients with listeriosis, revealed the strong and specific immunogenic capacity of the use of GAPDH nanovaccines as putative immunotherapies in listeriosis.
Authors
- David Salcines-Cuevas (ORCID: https://orcid.org/0000-0003-2627-0597)
- Carmen Alvarez-Domı́nguez (ORCID: https://orcid.org/0000-0002-4585-6959)
- José María Marimón (ORCID: https://orcid.org/0000-0002-2787-7094)
- Marco Marradi (ORCID: https://orcid.org/0000-0003-0831-6942)
- Javier Freire (ORCID: https://orcid.org/0009-0002-4168-7163)
- Javier Gonzalo Ocejo-Vinyals (ORCID: https://orcid.org/0000-0003-2245-4639)
- Javier Gómez‐Román (ORCID: https://orcid.org/0000-0002-2849-9435)
- Elena González-López (ORCID: https://orcid.org/0000-0002-0971-3045)
- Ricardo Calderón-González (ORCID: https://orcid.org/0000-0003-0841-3814)
- Noemí Montoya (ORCID: https://orcid.org/0000-0002-6659-8493)
- Jorge Calvo
- V Ictor Moreno-Torres'
- María Ubeda
- Vicente Soriano
- Elena Vazquez
Institutions
- Universidad de Cantabria (ES)
- Instituto de Salud Carlos III (ES)
- Marqués de Valdecilla University Hospital (ES)
- Biogipuzkoa Health Research Institute (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Universidad Internacional De La Rioja (ES)
- University of Florence (IT)
Publication Details
- Journal
- Emerging Microbes & Infections
- Published
- 2026-07-24
- DOI
- https://doi.org/10.1080/22221751.2026.2706316
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Firenze