Comparative genomics of herpes simplex virus 2 isolated from a maternal-neonatal dyad reveals high consensus sequence homology as well as minor variant diversity
Abstract Neonatal herpes simplex virus disease most often occurs following mother-to-neonate transmission during childbirth. However, genomic differences between the maternal and neonatal viral populations are poorly understood. Here, we performed deep whole-genome sequencing of clinical HSV-2 samples obtained from a maternal-neonatal dyad to investigate viral population dynamics during transmission.
Authors
- Reem Abu Rass (ORCID: https://orcid.org/0000-0001-9614-3847)
- Christopher D. Bowen (ORCID: https://orcid.org/0000-0003-4304-6255)
- Daniel W. Renner (ORCID: https://orcid.org/0000-0001-9878-8294)
- Lisa N. Akhtar (ORCID: https://orcid.org/0000-0002-6560-4185)
- Lacy M. Simons (ORCID: https://orcid.org/0000-0003-4041-6775)
- Moriah L Szpara
- Haley S Carter
Institutions
- Northwestern University (US)
- Center for Disease Dynamics, Economics & Policy (US)
- Northwestern University (PH)
- Lurie Children's Hospital (US)
Publication Details
- Journal
- Journal of the Pediatric Infectious Diseases Society
- Published
- 2026-07-23
- DOI
- https://doi.org/10.1093/jpids/piag064
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00