Approach to NMR Experiments with the Molten Objects Without Solvents

This article proposes an approach for acquiring HSQC (Heteronuclear Single Quantum Coherence) spectra using a high-resolution probehead originally designed for solutions. The method is suitable for studying organic substances with relatively low melting points, such as copolymers, composites, waxes, resins, and similar materials. The procedure involves preparing a melt of the substance directly inside the NMR (Nuclear Magnetic Resonance) sample tube prior to analysis. A comparison of HSQC spectra obtained from both the molten state and a solution of the same substance demonstrates that representative spectra can be acquired, enabling detailed analysis of their fine structure. The method has been successfully tested on a range of materials, including: paraffin, wax, honey, vanillin, polycaprolactone, a copolymer of lactide with phenol and maleic anhydride, composites of polycaprolactone and vanillin. This approach enables the identification of impurities in polymers and biological samples without requiring expensive deuterated solvents.