Successful Defibrillation After Conversion From Fixed‐Tilt to Tuned‐Duration Waveform
Fixed-tilt biphasic shocks may become ineffective in high-impedance states because phase-2 over-prolongation disrupts optimal charge neutralization. Waveform tuning based on membrane time constants, as implemented by DeFT Response, shortens phase durations to physiologic ranges and lowers the defibrillation threshold. This mechanism-based strategy may enhance the reliability of ICD therapy in patients with rising impedance or high DFTs.
Authors
- Yousaku Okubo (ORCID: https://orcid.org/0000-0003-4034-5356)
- Hisayasu Matsuzaki
- Shogo Miyamoto
- Hiroshi Oe
- Yukiko Nakano (ORCID: https://orcid.org/0000-0001-5373-5164)
Institutions
- Hiroshima University (JP)
- Hiroshima University Hospital (JP)
Publication Details
- Journal
- Journal of Arrhythmia
- Published
- 2026-07-24
- DOI
- https://doi.org/10.1002/joa3.70436
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00