Successful Defibrillation After Conversion From Fixed‐Tilt to Tuned‐Duration Waveform

Fixed-tilt biphasic shocks may become ineffective in high-impedance states because phase-2 over-prolongation disrupts optimal charge neutralization. Waveform tuning based on membrane time constants, as implemented by DeFT Response, shortens phase durations to physiologic ranges and lowers the defibrillation threshold. This mechanism-based strategy may enhance the reliability of ICD therapy in patients with rising impedance or high DFTs.

Authors

Institutions

Publication Details

Journal
Journal of Arrhythmia
Published
2026-07-24
DOI
https://doi.org/10.1002/joa3.70436
Primary Topic
Cardiac electrophysiology and arrhythmias
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Successful Defibrillation After Conversion From Fixed‐Tilt to Tuned‐Duration Waveform

Yousaku Okubo, Hisayasu Matsuzaki, Shogo Miyamoto, Hiroshi Oe et al.
Journal of Arrhythmia
Cardiac electrophysiology and arrhythmias
article

Successful Defibrillation After Conversion From Fixed‐Tilt to Tuned‐Duration Waveform

Yousaku Okubo, Hisayasu Matsuzaki, Shogo Miyamoto, Hiroshi Oe, Yukiko Nakano
article en

Abstract

Fixed-tilt biphasic shocks may become ineffective in high-impedance states because phase-2 over-prolongation disrupts optimal charge neutralization. Waveform tuning based on membrane time constants, as implemented by DeFT Response, shortens phase durations to physiologic ranges and lowers the defibrillation threshold. This mechanism-based strategy may enhance the reliability of ICD therapy in patients with rising impedance or high DFTs.

Journal of ArrhythmiaVol. 42(4)
Hiroshima University (JP), Hiroshima University Hospital (JP)
Affordable and clean energy
Openalex Percentile: Top 9%
Cardiac electrophysiology and arrhythmias
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.