Two newly isolated compounds from <i>Hansenia weberbaueriana</i> and their anti-inflammatory potential
An undescribed pyranocoumarin (1) and a new 4-pyranone derivative (2) were isolated from the roots of Hansenia weberbaueriana. Their structures were established based on spectroscopic evidence from HRESIMS and NMR, combined with ECD calculations. Among these newly isolated compounds, both 1 and 2 demonstrated anti-inflammatory potential by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages with IC50 values of 58.6 and 45.5 μM.
Authors
- Hu Su (ORCID: https://orcid.org/0000-0002-9672-944X)
- Da‐Le Guo (ORCID: https://orcid.org/0000-0003-3219-7066)
- J R Li
- Lijun Huang (ORCID: https://orcid.org/0000-0001-8072-5180)
- W. L. Dong (ORCID: https://orcid.org/0000-0001-9391-6154)
- Li Huang
- Li-Lian Zhao
- Yun Deng
- Wei-Jun Dong
Institutions
- Sichuan Entry-Exit Inspection and Quarantine Bureau (CN)
- Yibin University (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-07-23
- DOI
- https://doi.org/10.1080/14786419.2026.2706722
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China