IL-1–Activated Inflammatory Cardiac Fibroblasts Exacerbate Acute Coxsackievirus B3 Myocarditis
mice to specifically delete IL-1 signaling in fibroblasts. This targeted deletion reduced total cardiac inflammation by 45%-specifically lowering monocytes, T cells, and NK cells-without affecting viral clearance. By confirming the presence of IFs in endomyocardial biopsies from human patients, we have shown that fibroblast-specific IL-1 signaling is a critical driver of disease and a potential therapeutic target.
Authors
- Ina Sulkaj (ORCID: https://orcid.org/0000-0002-2494-8942)
- Martin Květoň (ORCID: https://orcid.org/0000-0002-8627-8059)
- Camille Jaime
- Ondřej Fabián (ORCID: https://orcid.org/0000-0002-0393-2415)
- Nadan Wang (ORCID: https://orcid.org/0000-0002-1682-080X)
- David S. Elias (ORCID: https://orcid.org/0000-0002-4363-3057)
- Daniela Čiháková (ORCID: https://orcid.org/0000-0002-8713-2860)
- Wonyoung Jo (ORCID: https://orcid.org/0009-0002-2392-900X)
- Vojtěch Melenovský
- Abdel Daoud
- Monica V. Talor
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Institute of Clinical and Experimental Medicine (CZ)
Publication Details
- Journal
- JACC Basic to Translational Science
- Published
- 2026-07-23
- DOI
- https://doi.org/10.1016/j.jacbts.2026.101637
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Global Autoimmune Institute
- American Heart Association
- National Institutes of Health