Clonal drift in the aging gut: Mapping the fate of stem cells over time

Aging tissues gradually lose cellular diversity due to stem cell exhaustion. A new PLOS Biology study utilizes advanced lineage tracing to track intestinal stem cell lineages across the life span. The findings reveal clonal attrition happens in early ages.

Authors

Tzu‐Chiao Lu (ORCID: https://orcid.org/0000-0001-9942-2307)
Hongjie Li (ORCID: https://orcid.org/0000-0002-7332-7122)

Institutions

Baylor College of Medicine (US)

Publication Details

Journal: PLoS Biology
Published: 2026-07-23
DOI: https://doi.org/10.1371/journal.pbio.3003928
Primary Topic: Cancer Cells and Metastasis
Type: article
Field-Weighted Citation Impact: 0.00

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article

Clonal drift in the aging gut: Mapping the fate of stem cells over time

Tzu‐Chiao Lu, Hongjie Li

Jul 23, 2026

PLoS Biology

Cancer Cells and Metastasis

article

Clonal drift in the aging gut: Mapping the fate of stem cells over time

Tzu‐Chiao Lu, Hongjie Li

July 23, 2026article en

Abstract

PLoS BiologyVol. 24(7)

Baylor College of Medicine (US)

Zero hunger

Openalex Percentile: Top 11%

Cancer Cells and Metastasis

DOI Open Access PDF OpenAlex

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Clonal drift in the aging gut: Mapping the fate of stem cells over time — Tzu‐Chiao Lu, Hongjie Li · PLoS Biology (2026) | TGRS Research Map | TGRS