Premise Plumbing “CT” (PPCT) as a Control Parameter for Opportunistic Pathogens

High Resolution Image Download MS PowerPoint Slide The product of disinfectant concentration and time (CT) is widely applied as a key pathogen inactivation parameter during potable water treatment. Here, we introduce the concept of premise plumbing CT (PPCT) as a part of an integrated framework for the control of opportunistic pathogens (OPs), such as Legionella pneumophila and Mycobacterium avium . A method is proposed for calculating CT at a given location in premise plumbing during stagnation events and demonstrated at scale in a chloraminated premise plumbing rig. Chloramine decay rates in stagnant PEX pipes were 2–3 orders of magnitude greater than in glass jars and dependent on initial chloramine concentration, contact time, temperature, pipe diameter, and flow rate. PPCT varied from 0 to 408 mg min/L from one pipe segment to another. No culturable L. pneumophila was detected in the test system pipes with PPCT > 78 mg min/L, which is comparable to reported CT thresholds for biofilm-associated L. pneumophila inactivation. Extending the concept to a lab-operated water heater yielded an estimated PPCT of 342.9 mg min/L, but robust growth of M. avium occurred in the tank up to 4 log CFU/mL, indicating extreme chloramine resistance. The PPCT framework introduced herein could provide a fundamental benchmark to help control OPs in the premise plumbing.

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Publication Details

Journal
ACS ES&T Water
Published
2026-07-23
DOI
https://doi.org/10.1021/acsestwater.6c00582
Primary Topic
Legionella and Acanthamoeba research
Type
article
Field-Weighted Citation Impact
0.00

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article

Premise Plumbing “CT” (PPCT) as a Control Parameter for Opportunistic Pathogens

Tolulope Odimayomi, Marc Edwards, William J. Rhoads, Amy J. Pruden et al.
ACS ES&T Water
Legionella and Acanthamoeba research
article

Premise Plumbing “CT” (PPCT) as a Control Parameter for Opportunistic Pathogens

Tolulope Odimayomi, Marc Edwards, William J. Rhoads, Amy J. Pruden, Myra D. Williams, Darel C. Snead, Joseph O. Falkinham
article en

Abstract

High Resolution Image Download MS PowerPoint Slide The product of disinfectant concentration and time (CT) is widely applied as a key pathogen inactivation parameter during potable water treatment. Here, we introduce the concept of premise plumbing CT (PPCT) as a part of an integrated framework for the control of opportunistic pathogens (OPs), such as Legionella pneumophila and Mycobacterium avium . A method is proposed for calculating CT at a given location in premise plumbing during stagnation events and demonstrated at scale in a chloraminated premise plumbing rig. Chloramine decay rates in stagnant PEX pipes were 2–3 orders of magnitude greater than in glass jars and dependent on initial chloramine concentration, contact time, temperature, pipe diameter, and flow rate. PPCT varied from 0 to 408 mg min/L from one pipe segment to another. No culturable L. pneumophila was detected in the test system pipes with PPCT > 78 mg min/L, which is comparable to reported CT thresholds for biofilm-associated L. pneumophila inactivation. Extending the concept to a lab-operated water heater yielded an estimated PPCT of 342.9 mg min/L, but robust growth of M. avium occurred in the tank up to 4 log CFU/mL, indicating extreme chloramine resistance. The PPCT framework introduced herein could provide a fundamental benchmark to help control OPs in the premise plumbing.

ACS ES&T Water
Vanda Institute (KH), Virginia Tech (US)
National Science Foundation, Edna Bailey Sussman Foundation, Virginia Polytechnic Institute and State University, Institute for Critical Technology and Applied Science
Clean water and sanitation
Openalex Percentile: Top 10%
Legionella and Acanthamoeba research
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Premise Plumbing “CT” (PPCT) as a Control Parameter for Opportunistic Pathogens — Tolulope Odimayomi, Marc Edwards, et al. · ACS ES&T Water (2026) | TGRS Research Map | TGRS