Urinary Leukotriene <scp> E <sub>4</sub> </scp> Enables Rule‐In Diagnosis of <scp>NSAID</scp> ‐Exacerbated Respiratory Disease
The data that support the findings of this study are available from the corresponding author upon reasonable request. Figure S1: Study flow diagram. N-ERD, nonsteroidal anti-inflammatory drug-exacerbated respiratory disease; NT-CRSwNP, NSAID-tolerant chronic rhinosinusitis with nasal polyps. Table S1: Baseline demographic characteristics of the discovery and validation cohorts. Table S2: Diagnostic performance of urinary LTE4 for identification of N-ERD in the validation cohort at two cutoff values. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Authors
- Patrick M. Vanderboom (ORCID: https://orcid.org/0000-0003-1341-1733)
- Rijul S. Kshirsagar (ORCID: https://orcid.org/0000-0002-3113-2685)
- Sergio E. Chiarella (ORCID: https://orcid.org/0000-0002-0445-4929)
- M. A. Vorobjeva (ORCID: https://orcid.org/0000-0002-6579-6869)
- Diane E. Grill (ORCID: https://orcid.org/0000-0002-8677-1724)
- Hamid R. Tizhoosh (ORCID: https://orcid.org/0000-0001-5488-601X)
- Erin K. O’Brien (ORCID: https://orcid.org/0000-0002-4891-9548)
- Hirohito Kita (ORCID: https://orcid.org/0000-0002-6854-2936)
- Kimberly G. Blumenthal (ORCID: https://orcid.org/0000-0003-4773-9817)
- Katherine N. Cahill (ORCID: https://orcid.org/0000-0002-8549-1835)
- C.‐C. Chen (ORCID: https://orcid.org/0000-0003-2581-1830)
- Masaki Orihara (ORCID: https://orcid.org/0000-0002-8182-9800)
- Rohit Divekar (ORCID: https://orcid.org/0000-0003-3836-1322)
- Anthony D. Maus (ORCID: https://orcid.org/0000-0003-3006-6265)
- Janalee K. Stokken (ORCID: https://orcid.org/0000-0002-1402-7461)
- Jacob G. Eide (ORCID: https://orcid.org/0000-0003-3727-8287)
- Elina Jerschow (ORCID: https://orcid.org/0000-0002-9066-2483)
- Golda Hudes
- Aleksandr iAkushev (ORCID: https://orcid.org/0009-0001-7040-7792)
- Alessandra Tomasello (ORCID: https://orcid.org/0009-0001-8508-7728)
- Nadeem Akbar (ORCID: https://orcid.org/0000-0001-6108-6985)
- Kayla Moehnke (ORCID: https://orcid.org/0009-0000-9007-4211)
- Patrick Colley (ORCID: https://orcid.org/0009-0007-8304-7339)
Institutions
- Albert Einstein College of Medicine (US)
- Mayo Clinic (US)
- Montefiore Medical Center (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Allergy
- Published
- 2026-07-23
- DOI
- https://doi.org/10.1111/all.70458
- Primary Topic
- Drug-Induced Adverse Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Mayo Clinic
- National Institute of Allergy and Infectious Diseases