Localizing Apparent Amyloid-β Clearance Along the Olfactory Lymphatic Route: Borneol Micelles as a Case Study

A lower brain amyloid-β signal or higher cervical-node signal does not identify the anatomical transport step affected. This Perspective uses the newly mapped mouse route through arachnoid fenestrations, olfactory dural and nasal lymphatics, and cervical lymph nodes to develop a spatiotemporal, segment-resolved framework. Borneol-micelle studies serve as a case study. Four competing explanations are separated: upstream parenchyma-to-CSF mobilization, altered delivery or passage at the arachnoid gateway, downstream olfactory or nasal lymphatic transport, and non-lymphatic redistribution. Acute minutes-to-hours transport is distinguished from days-to-weeks remodeling, and staged experiments specify segmental measurements and treatment-by-blockade interactions. This is a preprint of a Perspective prepared for journal submission and has not undergone peer review. No new data were created or analyzed. The article does not claim that borneol opens arachnoid fenestrations, treats Alzheimer disease, modifies chronic amyloid pathology, or has established human efficacy.