Fraserin A, a new chromanone isolated from the stem bark of <i>Calophyllum fraseri</i> M.R.Hend. & Wyatt-Sm.
A new chromanone, Fraserin A (1) was successfully isolated from the stem bark extract of Calophyllum fraseri, together with calolongic acid, isocalolongic acid, and apetalic acid. The characterisation and structural elucidation of the isolated compounds were established by extensive spectroscopic data analysis and comparison with literature data. The antimicrobial activity was tested using the broth microdilution assay, whereas activity on microbial biofilms were determined using a semi-quantitative static biofilm. Compound (1) exhibited significant activity against Candida albicans and Streptococcus mutans, with MIC value of 62.5 µg/mL. At 500 µg/mL, it showed antibiofilm activity, inhibiting biofilm formation against C. albicans (30.95%) and S. mutans (85.15%). These findings highlight Fraserin A as a biologically active chromanone with dual antimicrobial and biofilm-modulating properties.
Authors
- Nur Nabilah Mohd Zaini (ORCID: https://orcid.org/0009-0004-0847-489X)
- Кузиев Шерали Насруллоевич (ORCID: https://orcid.org/0000-0001-6667-9245)
- Feruzbek A. Khasanov (ORCID: https://orcid.org/0000-0001-8534-6235)
- David Barker (ORCID: https://orcid.org/0000-0002-3425-6552)
- Mohd Hafiz Arzmi (ORCID: https://orcid.org/0000-0002-9470-6412)
- Farkhod Eshboev (ORCID: https://orcid.org/0000-0003-3054-6111)
- Abubakar Siddiq Salihu (ORCID: https://orcid.org/0000-0002-4425-7524)
- Nurunajah Ab Ghani (ORCID: https://orcid.org/0000-0002-3602-6216)
- Wan Mohd Nuzul Hakimi Wan Salleh (ORCID: https://orcid.org/0000-0003-1408-229X)
- Ibragim Umbarov (ORCID: https://orcid.org/0000-0001-7155-4447)
- Madumar Musurmonov
Institutions
- Sultan Idris Education University (MY)
- University of Auckland (NZ)
- Umaru Musa Yar'adua University (NG)
- International Islamic University Malaysia (MY)
- Termez State University (UZ)
- National University of Uzbekistan (UZ)
- Westminster International University in Tashkent (UZ)
- Universiti Teknologi MARA (MY)
- National University of Malaysia (MY)
- MacDiarmid Institute for Advanced Materials and Nanotechnology (NZ)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-07-23
- DOI
- https://doi.org/10.1080/14786419.2026.2706057
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00