The pseudocirrhotic liver: Hepar lobatum carcinomatosum in a patient with triple-negative breast cancer

Hepar lobatum carcinomatosum (HLC) is a rare hepatic manifestation of metastatic malignancy that mimics cirrhosis in imaging and morphology but arises from entirely different pathophysiological mechanisms. Most commonly associated with breast cancer, particularly hormone-receptor-positive subtypes, HLC in the context of triple-negative breast cancer is extremely rare. This report presents the case of a 65-year-old woman with triple-negative breast cancer who developed progressive liver deformation consistent with HLC over a 12-month period, as documented by sequential computed tomography and Magnetic resonance imaging. Despite systemic chemotherapy, the liver showed marked lobulation, capsular retraction, and segmental atrophy in the absence of cirrhosis risk factors. Radiological features and clinical findings were analysed in light of current literature. The case emphasizes the need for heightened clinical suspicion and diagnostic accuracy to distinguish HLC from pseudocirrhosis and true cirrhosis, thereby improving patient management and prognosis.

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Publication Details

Journal
Radiology Case Reports
Published
2026-07-23
DOI
https://doi.org/10.1016/j.radcr.2026.06.094
Primary Topic
Breast Lesions and Carcinomas
Type
article
Field-Weighted Citation Impact
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article

The pseudocirrhotic liver: Hepar lobatum carcinomatosum in a patient with triple-negative breast cancer

Abderrahmane Ibenyahia, Soukaina Wakrim, Farah Boutaggount, Soufiane Bigi et al.
Radiology Case Reports
Breast Lesions and Carcinomas
article

The pseudocirrhotic liver: Hepar lobatum carcinomatosum in a patient with triple-negative breast cancer

Abderrahmane Ibenyahia, Soukaina Wakrim, Farah Boutaggount, Soufiane Bigi, Zahra Hami, Meryem Maskrout, Said Adnor, Ghizlane Rais, Zakaria Chahbi, N. Ziani, Houssam Rajad, Mohamed Ayez
article en

Abstract

Hepar lobatum carcinomatosum (HLC) is a rare hepatic manifestation of metastatic malignancy that mimics cirrhosis in imaging and morphology but arises from entirely different pathophysiological mechanisms. Most commonly associated with breast cancer, particularly hormone-receptor-positive subtypes, HLC in the context of triple-negative breast cancer is extremely rare. This report presents the case of a 65-year-old woman with triple-negative breast cancer who developed progressive liver deformation consistent with HLC over a 12-month period, as documented by sequential computed tomography and Magnetic resonance imaging. Despite systemic chemotherapy, the liver showed marked lobulation, capsular retraction, and segmental atrophy in the absence of cirrhosis risk factors. Radiological features and clinical findings were analysed in light of current literature. The case emphasizes the need for heightened clinical suspicion and diagnostic accuracy to distinguish HLC from pseudocirrhosis and true cirrhosis, thereby improving patient management and prognosis.

Radiology Case ReportsVol. 21(10)
Université Ibn Zohr (MA), Régie Autonome Multi Services D'Agadir (MA)
Good health and well-being
Openalex Percentile: Top 10%
Breast Lesions and Carcinomas
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