Effects of a Message‐Framing Video Intervention on Maternal Vaccine Confidence Regarding HPV Vaccination for Daughters: A Quasi‐Experimental Study Among Mothers With Cervical Intraepithelial Neoplasia

ABSTRACT Background Increasing HPV vaccination coverage is pivotal, necessitating effective vaccination strategies. This research assessed the impact of a message‐framing (MF) video intervention on boosting vaccine confidence among mothers diagnosed with cervical intraepithelial neoplasia (CIN), targeting HPV vaccination for their daughters. Methods Conducted from January to June 2024, this interventional study took place at the gynecological cervical clinic of a university‐affiliated hospital and targeted CIN patients from adjacent communities. Mothers with daughters aged 9–14 years, who were unvaccinated and whose mothers were diagnosed with CIN, participated. They were allocated to receive either standard health education or a targeted message‐framing video intervention. Outcome data were collected by trained researchers after a 10‐week intervention period, focusing on maternal knowledge, attitudes, and behaviors toward their daughters’ HPV vaccination. Results A total of 101 patients were analyzed. Those exposed to the message‐framing video intervention exhibited significantly improved knowledge, attitudes, and behaviors towards HPV vaccination ( Z = −3.376, P = 0.001), and demonstrated lower vaccine hesitancy scores ( Z = −2.924, P = 0.003) compared to their counterparts receiving standard health education. However, differences in the rates of scheduling vaccine appointments were not statistically significant between the groups ( χ 2 = 0.934, P = 0.334). Conclusions The message‐framing video intervention significantly enhanced vaccine confidence by improving the knowledge and willingness of CIN patients to vaccinate their daughters against HPV. Further studies are required to explore the intervention's influence on actual vaccination rates.