Enantioselective Access to Taxodione
A concise and enantioselective entry point to the quinone methide diterpene taxodione is presented. This synthesis was motivated by the distinct profiles of (+)-taxodine and (-)-taxodone in glioblastoma cell culture, which are delineated here for the first time.
Authors
- James H. Frederich (ORCID: https://orcid.org/0000-0003-2077-4436)
- Kyle J. Parella
- Vitalii S. Basistyi
- Zachary Deal
- Svetlana N Kononenko
Institutions
- Florida State University (US)
- Enzo Life Sciences (United States) (US)
- Cypress College (US)
Publication Details
- Journal
- Synthesis
- Published
- 2026-07-23
- DOI
- https://doi.org/10.1055/a-2922-6685
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health