Synthesis and Study of Antimicrobial and Antiradical Activity of N-Benzoylmethylamides of N-Substituted α,β-Dehydroamino Acids and the Corresponding Imidazol-4-ones
Abstract The synthesis of N-benzoylmethylamides of N-substituted α,β-dehydroamino acids and the corresponding 4H-imidazol-4-ones was carried out; their antibacterial, antifungal, and antiradical properties were studied. It was shown that among them, the compounds containing a nitro group in the meta- or para-position of the benzene ring of the arylidene residue exhibited the highest activity against E. coli, St. aureus, and Candida albicans.
Authors
- Samvel Chailyan (ORCID: https://orcid.org/0009-0001-1729-0716)
- Anna Sukiasyan (ORCID: https://orcid.org/0009-0003-9716-2777)
- A. A. Hovhannisyan (ORCID: https://orcid.org/0000-0003-0879-6800)
- Astghik A. Shahkhatuni (ORCID: https://orcid.org/0000-0003-1848-5256)
- V. O. Topuzyan (ORCID: https://orcid.org/0000-0002-1721-1993)
- Roza Madoyan (ORCID: https://orcid.org/0009-0003-0875-9302)
- A. G. Agababyan (ORCID: https://orcid.org/0000-0002-3812-0433)
- Sirvard G. Mangasaryan (ORCID: https://orcid.org/0009-0002-4053-1968)
Institutions
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
- Eurasia International University (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2026-07-23
- DOI
- https://doi.org/10.1134/s1070363226600736
- Primary Topic
- Synthesis of heterocyclic compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00