A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.

There is a higher density of immune cells in peritoneal fluid than is found in blood. Thus, any perturbations, from sterile injury to endometriosis to ovarian cancer, require immune cells to recognize and nucleate to these sites. Using peritoneal injuries as a prototype, we saw a massive recruitment of large peritoneal macrophages (LPMs) interspersed with mast cells. The mast cells were activated by sensory neurons to mobilize their 1-μm granules to the cell surface. Lattice light sheet microscopy unveiled a new step in the mast cell degranulation. After granules fused with the plasma membrane, cytonemes (very thin long filopodia) grabbed the granules from the mast cell surface and deposited them on neighboring LPMs. The granules were membraneless biomolecular condensates and harbored more than 200 different proteins, including MARCO, which mediated rapid LPM aggregation to the injury nidus. The condensates also induced a repair-like phenotype in the macrophages that helped heal the injury site.

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Publication Details

Journal
Open Access CRIS of the University of Bern
Published
2026-07-23
DOI
https://doi.org/10.48620/99746
Primary Topic
Mast cells and histamine
Type
article
Field-Weighted Citation Impact
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article

A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.

Bryan G. Yipp, Johnathan Canton, Oscar Tejada, Marco Fritzsche et al.
Open Access CRIS of the University of Bern
Mast cells and histamine
article

A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair.

Bryan G. Yipp, Johnathan Canton, Oscar Tejada, Marco Fritzsche, J. M. Bayer, Joël Zindel, Jonathon A. Ditlev, Song Huang, Raymond Shim, Nathan C. Peters, Justin Deniset, Paul Kubes, Afshin Derakhshani, Nina Noskovičová, Zeynep Baltaci, Matheus Batista Heitor Carneiro, Lilian Salm, Antoine Dufour, X Li, Monica Aida Lopez, Daniel Young, Mahamud Ur Rashid, Parisa Etemadi Nezhad, Claudia V Jakubzick, Edward Jenkins, Woo-Yong Lee, Ysbrand Nusse, Bayan Abou Mehrem, Michael L Dustin, Jeffrey B Mewburn
article en

Abstract

There is a higher density of immune cells in peritoneal fluid than is found in blood. Thus, any perturbations, from sterile injury to endometriosis to ovarian cancer, require immune cells to recognize and nucleate to these sites. Using peritoneal injuries as a prototype, we saw a massive recruitment of large peritoneal macrophages (LPMs) interspersed with mast cells. The mast cells were activated by sensory neurons to mobilize their 1-μm granules to the cell surface. Lattice light sheet microscopy unveiled a new step in the mast cell degranulation. After granules fused with the plasma membrane, cytonemes (very thin long filopodia) grabbed the granules from the mast cell surface and deposited them on neighboring LPMs. The granules were membraneless biomolecular condensates and harbored more than 200 different proteins, including MARCO, which mediated rapid LPM aggregation to the injury nidus. The condensates also induced a repair-like phenotype in the macrophages that helped heal the injury site.

Open Access CRIS of the University of Bern
Tracer Technologies (United States) (US)
Openalex Percentile: Top 15%
Mast cells and histamine
DOIOpen Access PDFOpenAlex
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