Safety Assessment of Polyhydroxystearic Acid, Poly(3-Hydroxyoctanoic Acid), and Polylactic Acid as Used in Cosmetics

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Polyhydroxystearic Acid, Poly(3-Hydroxyoctanoic Acid), and Polylactic Acid as used in cosmetic formulations. These ingredients are reported to function in cosmetics as a non-surfactant dispersing agent, a skin-conditioning agent, and an abrasive agent, respectively. The Panel reviewed the available data to determine the safety of these ingredients and concluded that these ingredients are safe in cosmetics in the present practices of use and concentrations described in this safety assessment.

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Publication Details

Journal
International Journal of Toxicology
Published
2026-07-23
DOI
https://doi.org/10.1177/10915818261469141
Primary Topic
Effects and risks of endocrine disrupting chemicals
Type
article
Field-Weighted Citation Impact
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article

Safety Assessment of Polyhydroxystearic Acid, Poly(3-Hydroxyoctanoic Acid), and Polylactic Acid as Used in Cosmetics

Paul W. Snyder, Monice M. Fiume, Preethi S. Raj, Susan C. Tilton et al.
International Journal of Toxicology
Effects and risks of endocrine disrupting chemicals
article

Safety Assessment of Polyhydroxystearic Acid, Poly(3-Hydroxyoctanoic Acid), and Polylactic Acid as Used in Cosmetics

Paul W. Snyder, Monice M. Fiume, Preethi S. Raj, Susan C. Tilton, Curtis D. Klaassen, Bart Heldreth, Thomas J. Slaga, Wilma F. Bergfeld, Donald V. Belsito, Allan E. Rettie, David E. Cohen, David Ross, Daniel C. Liebler
article en

Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Polyhydroxystearic Acid, Poly(3-Hydroxyoctanoic Acid), and Polylactic Acid as used in cosmetic formulations. These ingredients are reported to function in cosmetics as a non-surfactant dispersing agent, a skin-conditioning agent, and an abrasive agent, respectively. The Panel reviewed the available data to determine the safety of these ingredients and concluded that these ingredients are safe in cosmetics in the present practices of use and concentrations described in this safety assessment.

International Journal of Toxicology
Openalex Percentile: Top 11%
Effects and risks of endocrine disrupting chemicals
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